Inferring Somatic Mutation Rates Using the Stop-Enhanced Green Fluorescent Protein Mouse
نویسندگان
چکیده
منابع مشابه
Inferring somatic mutation rates using the stop-enhanced green fluorescent protein mouse.
A new method is developed for estimating rates of somatic mutation in vivo. The stop-enhanced green fluorescent protein (EGFP) transgenic mouse carries multiple copies of an EGFP gene with a premature stop codon. The gene can revert to a functional form via point mutations. Mice treated with a potent mutagen, N-ethyl-N-nitrosourea (ENU), and mice treated with a vehicle alone are assayed for mut...
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ژورنال
عنوان ژورنال: Genetics
سال: 2007
ISSN: 1943-2631
DOI: 10.1534/genetics.106.069310